| Function | APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells. |
| Protein Name | Apolipoprotein EApo-E |
| Database Links | Reactome: R-MMU-3000480Reactome: -MMU-381426Reactome: -MMU-8957275Reactome: -MMU-8963888Reactome: -MMU-8963901Reactome: -MMU-8964026Reactome: -MMU-8964058Reactome: -MMU-975634 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixExtracellular VesicleEndosomeMultivesicular BodyIn The PlasmaApoe Is Associated With ChylomicronsChylomicrons RemnantsVldlLdl And Hdl LipoproteinsLipid Poor Oligomeric Apoe Is Associated With The Extracellular Matrix In A Calcium- And Heparan-Sulfate Proteoglycans-Dependent MannerLipidation Induces The Release From The Extracellular MatrixColocalizes With Cd63 And Pmel At Exosomes And In Intraluminal Vesicles Within Multivesicular Endosomes |
| Alternative Protein Names | Apolipoprotein E proteinApo-E proteinApoe protein |
Information sourced from Uniprot.org
