| Tissue Specificity | Expressed in coronary endothelial cells (at protein level). Expressed in the embryo, allantoic and endothelial precursor cells of the yolk sac at 8 days post-coitum (dpc). Expressed in the secondary heart field and somite at 8.25 dpc. Expressed in fetal allantoic endothelial cells at 9 dpc. Expressed in the allantoid and the invading fetal vasculature of the placenta at 9.5 dpc. Expressed in endothelial cells adjacent to syncytiotrophoblast cells at 10.5 dpc. Expressed weakly in the embryonic heart at 11.5 dpc. Expressed in the adult heart. Expressed in endothelial cells and cardiomyocytes and weakly expressed in fibroblasts. |
| Post Translational Modifications | |
| Function | G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis. When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway leading to internalization of the receptor. APLNR/APJ receptor is also activated by mechanical strech in a G-protein-independent fashion to induce beta-arrestin signaling leading to cardiac hypertrophy. However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure and heart contractility and protection from cardiac hypertrophy and heart failure. |
| Protein Name | Apelin ReceptorAngiotensin Receptor-Like 1G-Protein Coupled Receptor ApjMsr |
| Database Links | Reactome: R-MMU-375276Reactome: -MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAfter Exposure To Apelin (Apln) Or Apelin Receptor Early Endogenous Ligand (Apela)Internalized From The Cell Surface Into An Endosomal Recycling CompartmentFrom Where It Is Recycled To The Cell Membrane |
| Alternative ELISA Names | Apelin Receptor ELISA kitAngiotensin Receptor-Like 1 ELISA kitG-Protein Coupled Receptor Apj ELISA kitMsr ELISA kitAplnr ELISA kitAgtrl1 ELISA kitApj ELISA kit |
| output | |
Information sourced from Uniprot.org
