Mouse ANGPT2/Ang2 protein (Recombinant) (N-His) (STJP009076)

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STJP009076
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse ANGPT2/Ang2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Angpt2
Gene ID: 11601
Uniprot ID: ANGP2_MOUSE
Immunogen Region: Asp283-Phe496
Immunogen: Mus musculus (Mouse)
Function Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.
Protein Name Angiopoietin-2
Ang-2
Database Links Reactome: R-MMU-210993
Cellular Localisation Secreted
Alternative Protein Names Angiopoietin-2 protein
Ang-2 protein
Angpt2 protein
Agpt2 protein

Information sourced from Uniprot.org

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