| Tissue Specificity | |
| Post Translational Modifications | In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin. |
| Function | Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor. Angiotensin-3: Stimulates aldosterone release. Angiotensin 1-7: Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. |
| Protein Name | AngiotensinogenSerpin A8 Cleaved Into - Angiotensin-1Angiotensin 1-10Angiotensin IAng I - Angiotensin-2Angiotensin 1-8Angiotensin IiAng Ii - Angiotensin-3Angiotensin 2-8Angiotensin IiiAng IiiDes-Asp1-Angiotensin Ii - Angiotensin-4Angiotensin 3-8Angiotensin IvAng Iv - Angiotensin 1-9 - Angiotensin 1-7 - Angiotensin 1-5 - Angiotensin 1-4 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Angiotensinogen ELISA kitSerpin A8 Cleaved Into - Angiotensin-1 ELISA kitAngiotensin 1-10 ELISA kitAngiotensin I ELISA kitAng I - Angiotensin-2 ELISA kitAngiotensin 1-8 ELISA kitAngiotensin Ii ELISA kitAng Ii - Angiotensin-3 ELISA kitAngiotensin 2-8 ELISA kitAngiotensin Iii ELISA kitAng Iii ELISA kitDes-Asp1-Angiotensin Ii - Angiotensin-4 ELISA kitAngiotensin 3-8 ELISA kitAngiotensin Iv ELISA kitAng Iv - Angiotensin 1-9 - Angiotensin 1-7 - Angiotensin 1-5 - Angiotensin 1-4 ELISA kitAgt ELISA kitSerpina8 ELISA kit |
| output | |
Information sourced from Uniprot.org
