| Host: | Sheep/Sheep |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | This ANG2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Conjugation: | Unconjugated/Biotin |
| Formulation: | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Purification: | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Determination Method: | Colormetric |
| Gene Symbol: | Angpt2 |
| Gene ID: | 11601 |
| Uniprot ID: | ANGP2_MOUSE |
| Immunogen: | Capture immunogen: Recombinant Mouse ANG2 protien.Detection Immunogen: Recombinant Mouse ANG2 protien. |
| Sample Type: | Serum, plasma and other biological fluids |
| Function | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis. |
| Protein Name | Angiopoietin-2Ang-2 |
| Database Links | Reactome: R-MMU-210993 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Angiopoietin-2 antibody pairAng-2 antibody pairAngpt2 antibody pairAgpt2 antibody pair |
Information sourced from Uniprot.org