• Mouse ALK-4/ACVR1B protein (Recombinant) (C-hFc) (STJP001969)

Mouse ALK-4/ACVR1B protein (Recombinant) (C-hFc) (STJP001969)

SKU:
STJP001969

Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse ALK-4/ACVR1B-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Acvr1b
Gene ID: 11479
Uniprot ID: ACV1B_MOUSE
Immunogen Region: Met1-Glu126
Immunogen: Recombinant Mouse ALK-4/ACVR1B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu126) of mouse ALK-4/ACVR1B (Accession #NP_031421.1) fused with 6×His tag at the C-terminus.
Function Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
Protein Name Activin Receptor Type-1b
Activin Receptor Type Ib
Actr-Ib
Activin Receptor-Like Kinase 4
Alk-4
Serine/Threonine-Protein Kinase Receptor R2
Skr2
Database Links Reactome: R-MMU-1502540
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Activin Receptor Type-1b protein
Activin Receptor Type Ib protein
Actr-Ib protein
Activin Receptor-Like Kinase 4 protein
Alk-4 protein
Serine/Threonine-Protein Kinase Receptor R2 protein
Skr2 protein
Acvr1b protein
Alk4 protein

Information sourced from Uniprot.org

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