| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Mouse CD166 at 10 Mu g/mL (100 Mu L/well) can bind Human CD6 with a linear range of 0.17-80.5 ng/mL. |
| Gene Symbol: | Alcam |
| Gene ID: | 11658 |
| Uniprot ID: | CD166_MOUSE |
| Immunogen Region: | Trp28-Lys527 |
| Immunogen: | Recombinant Mouse ALCAM/CD166 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Trp28-Lys527) of mouse ALCAM/CD166 (Accession #NP_033785.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | WYTVNSAYGDTIVMPCRLDV PQNLMFGKWKYEKPDGSPVF IAFRSSTKKSVQYDDVPEYK DRLSLSENYTLSIANAKISD EKRFVCMLVTEDNVFEAPTL VKVFKQPSKPEIVNKAPFLE TDQLKKLGDCISRDSYPDGN ITWYRNGKVLQPVEGEVAIL FKKEIDPGTQLYTVTSSLEY KTTRSDIQMPFTCSVTYYGP SGQKTIYSEQEIFDIYYPTE QVTIQVLPPKNAIKEGDNI |
| Post Translational Modifications | Glycosylated. |
| Function | Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis.required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation. Promotes neurite extension, axon growth and axon guidance.axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons. |
| Protein Name | Cd166 Antigen Activated Leukocyte Cell Adhesion Molecule Ben Protein Dm-Grasp Cd Antigen Cd166 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Projection Axon Dendrite Detected At The Immunological Synapse I E At The Contact Zone Between Antigen-Presenting Dendritic Cells And T-Cells Colocalizes With Cd6 And The Tcr/Cd3 Complex At The Immunological Synapse |
| Alternative Protein Names | Cd166 Antigen protein Activated Leukocyte Cell Adhesion Molecule protein Ben protein Protein Dm-Grasp protein Cd Antigen Cd166 protein Alcam protein |
Information sourced from Uniprot.org
