| Tissue Specificity | Detected on brain motor neurons, in differentiating retinal ganglion cells and in adult retina. Detected on leukocytes and on lymphatic endothelial cells. Detected in spleen B cells and T-cells (at protein level). Detected in adult brain and embryonic spinal cord. Expressed at high levels in the brain, and lung, and at lower levels in the liver, and the kidney, as well as by activated leukocytes. |
| Post Translational Modifications | Glycosylated. |
| Function | Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis.required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation. Promotes neurite extension, axon growth and axon guidance.axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons. |
| Protein Name | Cd166 AntigenActivated Leukocyte Cell Adhesion MoleculeBenProtein Dm-GraspCd Antigen Cd166 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonDendriteDetected At The Immunological SynapseIEAt The Contact Zone Between Antigen-Presenting Dendritic Cells And T-CellsColocalizes With Cd6 And The Tcr/Cd3 Complex At The Immunological Synapse |
| Alternative Protein Names | Cd166 Antigen proteinActivated Leukocyte Cell Adhesion Molecule proteinBen proteinProtein Dm-Grasp proteinCd Antigen Cd166 proteinAlcam protein |
Information sourced from Uniprot.org
