| Short Description : | Recombinant-Mouse 4-1BB (CD137)-protein was developed from cho cells. For use in research applications. |
| Host: | CHO Cells |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised 0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction: | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Gene Symbol: | Tnfrsf9 |
| Gene ID: | 21942 |
| Uniprot ID: | TNR9_MOUSE |
| Immunogen: | Optimized DNA sequence encoding Mouse 4-1BB (CD137) fused to a C terminal IgG1 Fc tag was expressed in CHO Cells. NA |
| Immunogen Region: | C-Term |
| Tissue Specificity | Expressed in activated thymocytes, splenic T cells, CD4(+), and CD8(+) T-cells. |
| Function | Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 94-1bb Ligand ReceptorT-Cell Antigen 4-1bbCd Antigen Cd137 |
| Database Links | Reactome: R-MMU-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 9 protein4-1bb Ligand Receptor proteinT-Cell Antigen 4-1bb proteinCd Antigen Cd137 proteinTnfrsf9 proteinCd137 proteinIla proteinLy63 protein |
Information sourced from Uniprot.org
