Mitofusin 2 Blocking Peptide peptide (STJ504372)

SKU:
STJ504372-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mitofusin 2 Blocking Peptide is synthetically produced from the 543-593 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: MFN2
Gene ID: 9927
Uniprot ID: MFN2_HUMAN
Immunogen Region: 543-593
Immunogen: Synthetic peptide taken within amino acid region 543-593 on human Mitofusin 2 protein.
Tissue Specificity Ubiquitous.expressed at low level. Highly expressed in heart and kidney.
Post Translational Modifications Phosphorylated by PINK1. Ubiquitinated by non-degradative ubiquitin by PRKN, promoting mitochondrial fusion.deubiquitination by USP30 inhibits mitochondrial fusion. Ubiquitinated by HUWE1 when dietary stearate (C18:0) levels are low.ubiquitination inhibits mitochondrial fusion.
Function Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
Peptide Name Mitofusin-2
Transmembrane Gtpase Mfn2
Database Links Reactome: R-HSA-5205685
Reactome: R-HSA-9013419
Reactome: R-HSA-983231
Cellular Localisation Mitochondrion Outer Membrane
Multi-Pass Membrane Protein
Colocalizes With Bax During Apoptosis
Alternative Peptide Names Mitofusin-2 protein
Transmembrane Gtpase Mfn2 protein
MFN2 protein
CPRP1 protein
KIAA0214 protein

Information sourced from Uniprot.org

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