| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
MAPK7 Blocking Peptide for STJ501713 is synthetically produced from the 700-750 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
MAPK7 |
| Gene ID: |
5598 |
| Uniprot ID: |
MK07_HUMAN |
| Immunogen Region: |
700-750 |
| Specificity: |
This blocking peptide is recommended for use in combination with MAPK7 antibody, STJ501713 |
| Immunogen: |
Synthetic peptide taken within amino acid region 700-750 on human Mitogen-activated protein kinase 7. |
| Tissue Specificity | Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. |
| Post Translational Modifications | Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme. Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent. |
| Function | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. |
| Peptide Name | Mitogen-Activated Protein Kinase 7Map Kinase 7Mapk 7Big Map Kinase 1Bmk-1Extracellular Signal-Regulated Kinase 5Erk-5 |
| Database Links | Reactome: R-HSA-198753Reactome: R-HSA-198765Reactome: R-HSA-202670Reactome: R-HSA-2559582Reactome: R-HSA-881907Reactome: R-HSA-8853659 |
| Cellular Localisation | CytoplasmNucleusPml BodyTranslocates To The Nucleus Upon Activation |
| Alternative Peptide Names | Mitogen-Activated Protein Kinase 7 proteinMap Kinase 7 proteinMapk 7 proteinBig Map Kinase 1 proteinBmk-1 proteinExtracellular Signal-Regulated Kinase 5 proteinErk-5 proteinMAPK7 proteinBMK1 proteinERK5 proteinPRKM7 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
