| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
MAPK4 Blocking Peptide for STJ501706 is synthetically produced from the 500-550 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
MAPK4 |
| Gene ID: |
5596 |
| Uniprot ID: |
MK04_HUMAN |
| Immunogen Region: |
500-550 |
| Specificity: |
This blocking peptide is recommended for use in combination with MAPK4 antibody, STJ501706 |
| Immunogen: |
Synthetic peptide taken within amino acid region 500-550 on human Mitogen-activated protein kinase 4. |
| Tissue Specificity | High expression in heart and brain. |
| Post Translational Modifications | Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. |
| Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. |
| Peptide Name | Mitogen-Activated Protein Kinase 4Map Kinase 4Mapk 4Extracellular Signal-Regulated Kinase 4Erk-4Map Kinase Isoform P63P63-Mapk |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | CytoplasmNucleusTranslocates To The Cytoplasm Following Interaction With Mapkapk5 |
| Alternative Peptide Names | Mitogen-Activated Protein Kinase 4 proteinMap Kinase 4 proteinMapk 4 proteinExtracellular Signal-Regulated Kinase 4 proteinErk-4 proteinMap Kinase Isoform P63 proteinP63-Mapk proteinMAPK4 proteinERK4 proteinPRKM4 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
