MANF protein (STJP000139)

SKU:
STJP000139

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Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: MANF-protein was developed from. For use in research applications.
Formulation: PBS pH 7.4, concentration
Purification: Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media
Concentration: 1 mg/ml
Storage Instruction: Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Gene Symbol: MANF
Gene ID: 7873
Uniprot ID: MANF_HUMAN
Post Translational Modifications May contain sialic acid residues.
Function Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions.
Protein Name Mesencephalic Astrocyte-Derived Neurotrophic Factor
Arginine-Rich Protein
Protein Armet
Database Links Reactome: R-HSA-114608
Cellular Localisation Secreted
Endoplasmic Reticulum Lumen
Sarcoplasmic Reticulum Lumen
Retained In The Endoplasmic Reticulum (Er)
And Sarcoplasmic Reticulum (Sr) Under Normal Conditions
Up-Regulated And Secreted By The Er/Sr In Response To Er Stress And Hypoxia
Alternative Protein Names Mesencephalic Astrocyte-Derived Neurotrophic Factor protein
Arginine-Rich Protein protein
Protein Armet protein
MANF protein
ARMET protein
ARP protein

Information sourced from Uniprot.org

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