| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
MANF-protein was developed from. For use in research applications. |
| Formulation: |
PBS pH 7.4, concentration |
| Purification: |
Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media |
| Concentration: |
1 mg/ml |
| Storage Instruction: |
Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
| Post Translational Modifications | May contain sialic acid residues. |
| Function | Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions. |
| Protein Name | Mesencephalic Astrocyte-Derived Neurotrophic FactorArginine-Rich ProteinProtein Armet |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | SecretedEndoplasmic Reticulum LumenSarcoplasmic Reticulum LumenRetained In The Endoplasmic Reticulum (Er)And Sarcoplasmic Reticulum (Sr) Under Normal ConditionsUp-Regulated And Secreted By The Er/Sr In Response To Er Stress And Hypoxia |
| Alternative Protein Names | Mesencephalic Astrocyte-Derived Neurotrophic Factor proteinArginine-Rich Protein proteinProtein Armet proteinMANF proteinARMET proteinARP protein |
Information sourced from Uniprot.org
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