| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
LOXL1 Positive Control for STJ501635 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500-1:1, 000 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Loxl1 |
| Gene ID: |
16949 |
| Uniprot ID: |
LOXL1_MOUSE |
| Specificity: |
This is positive control is recommended for use in combination with LOXL1 antibody STJ501635. |
| Post Translational Modifications | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytic proccessing by a furin-like protease causes removal of N-terminal propeptide resulting in an enzyme largely inactive, but further proteolytic processing by BMP1 results in enzyme activation. |
| Function | Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. Essential for the elastic fiber homeostasis and for their maintenance at adult age. |
| Peptide Name | Lysyl Oxidase Homolog 1Lysyl Oxidase 2Lysyl Oxidase-Like Protein 1 |
| Database Links | Reactome: R-MMU-1566948Reactome: -MMU-2243919 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Peptide Names | Lysyl Oxidase Homolog 1 proteinLysyl Oxidase 2 proteinLysyl Oxidase-Like Protein 1 proteinLoxl1 proteinLox2 proteinLoxl protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
