| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
LILRB3 Positive Control for STJ501608 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
LILRB3 |
| Gene ID: |
102725035/107987462 |
| Uniprot ID: |
LIRB3_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with LILRB3 antibody STJ501608. |
| Tissue Specificity | Detected in monocytes and B-cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2. |
| Function | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). |
| Peptide Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3Lir-3Leukocyte Immunoglobulin-Like Receptor 3Cd85 Antigen-Like Family Member AImmunoglobulin-Like Transcript 5Ilt-5Monocyte Inhibitory Receptor Hl9Cd Antigen Cd85a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Peptide Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 proteinLir-3 proteinLeukocyte Immunoglobulin-Like Receptor 3 proteinCd85 Antigen-Like Family Member A proteinImmunoglobulin-Like Transcript 5 proteinIlt-5 proteinMonocyte Inhibitory Receptor Hl9 proteinCd Antigen Cd85a proteinLILRB3 proteinILT5 proteinLIR3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
