LILRB3 Blocking Peptide for STJ501605 peptide (STJ504297)

SKU:
STJ504297-250
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : LILRB3 Blocking Peptide for STJ501605 is synthetically produced from the 800-841 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Lilrb3
Gene ID: 18733
Uniprot ID: LIRB3_MOUSE
Immunogen Region: 800-841
Specificity: This blocking peptide is recommended for use in combination with LILRB3 antibody, STJ501605
Immunogen: Synthetic peptide taken within amino acid region 800-841 on mouse LILRB3 protein.
Tissue Specificity Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells.
Post Translational Modifications Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-794 and Tyr-824 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.
Function May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Peptide Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3
Lir-3
Leukocyte Immunoglobulin-Like Receptor 3
Cell-Surface Glycoprotein P91
Paired Immunoglobulin-Like Receptor B
Pir-B
Database Links Reactome: R-MMU-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Peptide Names Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 protein
Lir-3 protein
Leukocyte Immunoglobulin-Like Receptor 3 protein
Cell-Surface Glycoprotein P91 protein
Paired Immunoglobulin-Like Receptor B protein
Pir-B protein
Lilrb3 protein
Pirb protein

Information sourced from Uniprot.org

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