| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
LILRB3 Blocking Peptide for STJ501605 is synthetically produced from the 800-841 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Lilrb3 |
| Gene ID: |
18733 |
| Uniprot ID: |
LIRB3_MOUSE |
| Immunogen Region: |
800-841 |
| Specificity: |
This blocking peptide is recommended for use in combination with LILRB3 antibody, STJ501605 |
| Immunogen: |
Synthetic peptide taken within amino acid region 800-841 on mouse LILRB3 protein. |
| Tissue Specificity | Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-794 and Tyr-824 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2. |
| Function | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). |
| Peptide Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3Lir-3Leukocyte Immunoglobulin-Like Receptor 3Cell-Surface Glycoprotein P91Paired Immunoglobulin-Like Receptor BPir-B |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Peptide Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 proteinLir-3 proteinLeukocyte Immunoglobulin-Like Receptor 3 proteinCell-Surface Glycoprotein P91 proteinPaired Immunoglobulin-Like Receptor B proteinPir-B proteinLilrb3 proteinPirb protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
