| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Phospho-JAK1 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | JAK1 |
| Gene ID: | 3716 |
| Uniprot ID: | JAK1_HUMAN |
| Tissue Specificity | Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. |
| Post Translational Modifications | Autophosphorylated. Phosphorylated by TYK2 on tyrosine residues in response to type-I interferon signaling, leading to its activation. Phosphorylated on tyrosine residues in response to interferon gamma signaling. Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling. Ubiquitinated by RNF125.leading to its degradation by the proteasome. |
| Function | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. |
| Peptide Name | Tyrosine-Protein Kinase Jak1 Janus Kinase 1 Jak-1 |
| Database Links | Reactome: R-HSA-1059683 Reactome: R-HSA-110056 Reactome: R-HSA-112411 Reactome: R-HSA-1169408 Reactome: R-HSA-1266695 Reactome: R-HSA-449836 Reactome: R-HSA-5673001 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-6788467 Reactome: R-HSA-877300 Reactome: R-HSA-877312 Reactome: R-HSA-8854691 Reactome: R-HSA-8983432 Reactome: R-HSA-8984722 Reactome: R-HSA-8985947 Reactome: R-HSA-9020558 Reactome: R-HSA-9020591 Reactome: R-HSA-9020956 Reactome: R-HSA-9020958 Reactome: R-HSA-909733 Reactome: R-HSA-912526 Reactome: R-HSA-912694 Reactome: R-HSA-9674555 Reactome: R-HSA-9679191 Reactome: R-HSA-9705462 Reactome: R-HSA-9705671 Reactome: R-HSA-9732724 Reactome: R-HSA-9833109 |
| Cellular Localisation | Endomembrane System Peripheral Membrane Protein Wholly Intracellular Possibly Membrane Associated |
| Alternative Peptide Names | Tyrosine-Protein Kinase Jak1 protein Janus Kinase 1 protein Jak-1 protein JAK1 protein JAK1A protein JAK1B protein |
Information sourced from Uniprot.org