| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Phospho-JAK1 Blocking Peptide is synthetically produced from the 1000-1050 sequence and is suitable for use in western blot applications. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | JAK1 |
| Gene ID: | 3716 |
| Uniprot ID: | JAK1_HUMAN |
| Immunogen Region: | 1000-1050 |
| Immunogen: | Synthetic peptide taken within amino acid region 1000-1050 on human JAK1 protein. Phosphorylated 1034 & 1035 tyrosine residues. |
| Tissue Specificity | Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. |
| Post Translational Modifications | Autophosphorylated. Phosphorylated by TYK2 on tyrosine residues in response to type-I interferon signaling, leading to its activation. Phosphorylated on tyrosine residues in response to interferon gamma signaling. Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling. Ubiquitinated by RNF125.leading to its degradation by the proteasome. |
| Function | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. |
| Peptide Name | Tyrosine-Protein Kinase Jak1Janus Kinase 1Jak-1 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-110056Reactome: R-HSA-112411Reactome: R-HSA-1169408Reactome: R-HSA-1266695Reactome: R-HSA-449836Reactome: R-HSA-5673001Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-6788467Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-8854691Reactome: R-HSA-8983432Reactome: R-HSA-8984722Reactome: R-HSA-8985947Reactome: R-HSA-9020558Reactome: R-HSA-9020591Reactome: R-HSA-9020956Reactome: R-HSA-9020958Reactome: R-HSA-909733Reactome: R-HSA-912526Reactome: R-HSA-912694Reactome: R-HSA-9674555Reactome: R-HSA-9679191Reactome: R-HSA-9705462Reactome: R-HSA-9705671Reactome: R-HSA-9732724 |
| Cellular Localisation | Endomembrane SystemPeripheral Membrane ProteinWholly IntracellularPossibly Membrane Associated |
| Alternative Peptide Names | Tyrosine-Protein Kinase Jak1 proteinJanus Kinase 1 proteinJak-1 proteinJAK1 proteinJAK1A proteinJAK1B protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance