| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ITPR2 Positive Control for STJ501517 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Itpr2 |
| Gene ID: |
81678 |
| Uniprot ID: |
ITPR2_RAT |
| Specificity: |
This is positive control is recommended for use in combination with ITPR2 antibody STJ501517. |
| Post Translational Modifications | Phosphorylation by CaMK2 on Ser-150 significantly decreases the channel open probability. Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. |
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states.a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity. |
| Peptide Name | Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2Ip3 Receptor Isoform 2Ip3r 2Insp3r2Inositol 1 -4 -5-Trisphosphate Receptor Type 2Type 2 Inositol 1 -4 -5-Trisphosphate ReceptorType 2 Insp3 Receptor |
| Database Links | Reactome: R-RNO-114508Reactome: -RNO-139853Reactome: -RNO-381676Reactome: -RNO-5578775Reactome: -RNO-983695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleSecretory Vesicle MembraneForms Clusters On Endoplasmic Reticulum Membrane Upon Inositol 145-Trisphosphate Binding |
| Alternative Peptide Names | Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2 proteinIp3 Receptor Isoform 2 proteinIp3r 2 proteinInsp3r2 proteinInositol 1 -4 -5-Trisphosphate Receptor Type 2 proteinType 2 Inositol 1 -4 -5-Trisphosphate Receptor proteinType 2 Insp3 Receptor proteinItpr2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
