IRAKM Positive Control peptide (STJ505670)

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STJ505670-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : IRAKM Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:2, 500-1:5, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: IRAK3
Gene ID: 11213
Uniprot ID: IRAK3_HUMAN
Immunogen: Purified Interleukin-1 receptor-associated kinase 3 protein.
Tissue Specificity Expressed in eosinophils, dendritic cells and/or monocytes (at protein level). Expressed predominantly in peripheral blood lymphocytes.
Function Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells.
Peptide Name Interleukin-1 Receptor-Associated Kinase 3
Irak-3
Il-1 Receptor-Associated Kinase M
Irak-M
Inactive Il-1 Receptor-Associated Kinase 3
Database Links Reactome: R-HSA-166058
Reactome: R-HSA-9020702
Cellular Localisation Cytoplasm
Nucleus
In Dendritic Cells
Translocates Into The Nucleus Upon Il33 Stimulation
Alternative Peptide Names Interleukin-1 Receptor-Associated Kinase 3 protein
Irak-3 protein
Il-1 Receptor-Associated Kinase M protein
Irak-M protein
Inactive Il-1 Receptor-Associated Kinase 3 protein
IRAK3 protein

Information sourced from Uniprot.org

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