Integrin linked ILK Positive Control peptide (STJ504318)

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STJ504318-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Integrin linked ILK Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ILK
Gene ID: 3611
Uniprot ID: ILK_HUMAN
Tissue Specificity Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
Post Translational Modifications Autophosphorylated on serine residues.
Function Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Peptide Name Integrin-Linked Protein Kinase
59 Kda Serine/Threonine-Protein Kinase
Beta-Integrin-Linked Kinase
Ilk-1
Ilk-2
P59ilk
Database Links Reactome: R-HSA-446343
Reactome: R-HSA-446353
Cellular Localisation Cell Junction
Focal Adhesion
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Projection
Lamellipodium
Cytoplasm
Myofibril
Sarcomere
Alternative Peptide Names Integrin-Linked Protein Kinase protein
59 Kda Serine/Threonine-Protein Kinase protein
Beta-Integrin-Linked Kinase protein
Ilk-1 protein
Ilk-2 protein
P59ilk protein
ILK protein
ILK1 protein
ILK2 protein

Information sourced from Uniprot.org

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