Tissue Specificity | Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%). |
Function | Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance. |
Peptide Name | Indoleamine 2 -3-Dioxygenase 2Ido-2Indoleamine 2 -3-Dioxygenase-Like Protein 1Indoleamine-Pyrrole 2 -3-Dioxygenase-Like Protein 1 |
Database Links | Reactome: R-HSA-71240 |
Alternative Peptide Names | Indoleamine 2 -3-Dioxygenase 2 proteinIdo-2 proteinIndoleamine 2 -3-Dioxygenase-Like Protein 1 proteinIndoleamine-Pyrrole 2 -3-Dioxygenase-Like Protein 1 proteinIDO2 proteinINDOL1 protein |
Information sourced from Uniprot.org