Indoleamine 2 3-dioxygenase 1 Positive Control peptide (STJ505584)

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STJ505584-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Indoleamine 2 3-dioxygenase 1 Positive Control is synthetically produced from the 100-150 sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: IDO1
Gene ID: 3620
Uniprot ID: I23O1_HUMAN
Immunogen Region: 100-150
Immunogen: Synthetic peptide taken within amino acid region 100-150 on human Indoleamine 2, 3-dioxygenase 1 protein.
Function Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection.
Peptide Name Indoleamine 2 -3-Dioxygenase 1
Ido-1
Indoleamine-Pyrrole 2 -3-Dioxygenase
Database Links Reactome: R-HSA-71240
Cellular Localisation Cytoplasm
Cytosol
Alternative Peptide Names Indoleamine 2 -3-Dioxygenase 1 protein
Ido-1 protein
Indoleamine-Pyrrole 2 -3-Dioxygenase protein
IDO1 protein
IDO protein
INDO protein

Information sourced from Uniprot.org

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