| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
IL17C1 Blocking Peptide is synthetically produced from the 70-120 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
IL17RC |
| Gene ID: |
84818 |
| Uniprot ID: |
I17RC_HUMAN |
| Immunogen Region: |
70-120 |
| Immunogen: |
Synthetic peptide taken within amino acid region 70-120 on IL17RC1 protein common to C2 and C5. |
| Function | Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA. Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA. Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway. Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. Isoform 5: Receptor for both IL17A and IL17F. Isoform 6: Does not bind IL17A or IL17F. Isoform 7: Does not bind IL17A or IL17F. Isoform 8: Receptor for both IL17A and IL17F. |
| Peptide Name | Interleukin-17 Receptor CIl-17 Receptor CIl-17rcInterleukin-17 Receptor HomologIl17rhomInterleukin-17 Receptor-Like ProteinIl-17rlZcytor14 |
| Database Links | Reactome: R-HSA-448424Reactome: R-HSA-9705671 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSoluble Isoforms May Be Produced |
| Alternative Peptide Names | Interleukin-17 Receptor C proteinIl-17 Receptor C proteinIl-17rc proteinInterleukin-17 Receptor Homolog proteinIl17rhom proteinInterleukin-17 Receptor-Like Protein proteinIl-17rl proteinZcytor14 proteinIL17RC proteinUNQ6118 proteinPRO20040 proteinPRO38901 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
