Human ZRANB3 protein (Recombinant) (N-His) (STJP008912)

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STJP008912
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ZRANB3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ZRANB3
Gene ID: 84083
Uniprot ID: ZRAB3_HUMAN
Immunogen Region: Asp27-Arg256
Immunogen: Homo sapiens (Human)
Function DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.
Protein Name Dna Annealing Helicase And Endonuclease Zranb3
Annealing Helicase 2
Ah2
Zinc Finger Ran-Binding Domain-Containing Protein 3 Includes - Dna Annealing Helicase Zranb3 - Endonuclease Zranb3
Cellular Localisation Nucleus
Chromosome
Following Dna Damage
Recruited To Sites Of Dna Damage And Stalled Replication Forks By Polyubiquitinated Pcna
Alternative Protein Names Dna Annealing Helicase And Endonuclease Zranb3 protein
Annealing Helicase 2 protein
Ah2 protein
Zinc Finger Ran-Binding Domain-Containing Protein 3 Includes - Dna Annealing Helicase Zranb3 - Endonuclease Zranb3 protein
ZRANB3 protein

Information sourced from Uniprot.org