| Post Translational Modifications | Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation. O-glycosylated. O-GlcNAcylation may occur in response to increasing glucose levels and affect transcription factor activity. |
| Function | Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells. May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose. However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4. |
| Protein Name | Zinc Finger Protein 410Another Partner For Arf 1 |
| Cellular Localisation | NucleusChromosomeDirectly Binds To The Sequence Motif 5'-Catcccataata-3' |
| Alternative Protein Names | Zinc Finger Protein 410 proteinAnother Partner For Arf 1 proteinZNF410 proteinAPA1 protein |
Information sourced from Uniprot.org
