Human ZEB1 protein (Recombinant) (N-GST & C-His) (STJP007335)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ZEB1-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ZEB1 |
| Gene ID | 6935 |
| Uniprot ID | ZEB1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser583-Glu643 |
Additional Info
| Post Translational Modifications | Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP51, leading to stabilization. |
| Function | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region. |
| Protein Name | Zinc Finger E-Box-Binding Homeobox 1Nil-2-A Zinc Finger ProteinNegative Regulator Of Il2Transcription Factor 8Tcf-8 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9926550 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Zinc Finger E-Box-Binding Homeobox 1 proteinNil-2-A Zinc Finger Protein proteinNegative Regulator Of Il2 proteinTranscription Factor 8 proteinTcf-8 proteinZEB1 proteinAREB6 proteinTCF8 protein |
Information sourced from Uniprot.org