Human ZC3HAV1 protein (Recombinant) (N-His) (STJP007468)

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STJP007468
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ZC3HAV1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ZC3HAV1
Gene ID: 56829
Uniprot ID: ZCCHV_HUMAN
Immunogen Region: Met1-Asn227
Immunogen: Homo sapiens (Human)
Function Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
Protein Name Zinc Finger Ccch-Type Antiviral Protein 1
Adp-Ribosyltransferase Diphtheria Toxin-Like 13
Artd13
Inactive Poly Adp-Ribose Polymerase 13
Parp13
Zinc Finger Ccch Domain-Containing Protein 2
Zinc Finger Antiviral Protein
Zap
Database Links Reactome: R-HSA-6802952
Cellular Localisation Isoform 1: Cytoplasm
Nucleus
Localizes In The Cytoplasm At Steady State
But Shuttles Between Nucleus And Cytoplasm In A Xpo1-Dependent Manner
Isoform 2: Cytoplasm
Alternative Protein Names Zinc Finger Ccch-Type Antiviral Protein 1 protein
Adp-Ribosyltransferase Diphtheria Toxin-Like 13 protein
Artd13 protein
Inactive Poly Adp-Ribose Polymerase 13 protein
Parp13 protein
Zinc Finger Ccch Domain-Containing Protein 2 protein
Zinc Finger Antiviral Protein protein
Zap protein
ZC3HAV1 protein
ZC3HDC2 protein
PRO1677 protein

Information sourced from Uniprot.org

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