| Function | Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. |
| Protein Name | Telomere Zinc Finger-Associated ProteinTzapKrueppel-Related Zinc Finger Protein 3Hkr3Zinc Finger And Btb Domain-Containing Protein 48Zinc Finger Protein 855 |
| Cellular Localisation | NucleusChromosomeTelomereDirectly Binds The Telomeric Double-Stranded 5'-Ttaggg-3' RepeatAccording To A ReportPreferentially Binds To Long Telomeres That Have A Low Concentration Of Shelterin ComplexCompeting With The Telomeric Repeat Binding Factors Terf1 And Terf2According To Another ReportBinds Telomeres Regardless Of Their Length |
| Alternative Protein Names | Telomere Zinc Finger-Associated Protein proteinTzap proteinKrueppel-Related Zinc Finger Protein 3 proteinHkr3 proteinZinc Finger And Btb Domain-Containing Protein 48 proteinZinc Finger Protein 855 proteinZBTB48 proteinHKR3 proteinTZAP proteinZNF855 protein |
Information sourced from Uniprot.org
