| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human YWHAZ-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | YWHAZ |
| Gene ID: | 7534 |
| Uniprot ID: | 1433Z_HUMAN |
| Immunogen Region: | Met1-Asn245 |
| Immunogen: | Homo sapiens (Human) |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity. |
| Protein Name | 14-3-3 Protein Zeta/DeltaProtein Kinase C Inhibitor Protein 1Kcip-1 |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-3769402Reactome: R-HSA-392517Reactome: R-HSA-430116Reactome: R-HSA-450604Reactome: R-HSA-512988Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-75035Reactome: R-HSA-9013700Reactome: R-HSA-9604323Reactome: R-HSA-9614399Reactome: R-HSA-9735871Reactome: R-HSA-9755779 |
| Cellular Localisation | CytoplasmMelanosomeLocated To Stage I To Stage Iv Melanosomes |
| Alternative Protein Names | 14-3-3 Protein Zeta/Delta proteinProtein Kinase C Inhibitor Protein 1 proteinKcip-1 proteinYWHAZ protein |
Information sourced from Uniprot.org