Human YTHDC2 protein (Recombinant) (N-His) (STJP007704)

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STJP007704
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Short Description :Recombinant-Human YTHDC2-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:YTHDC2
Gene ID:64848
Uniprot ID:YTDC2_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Glu185-Gly361
Function 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis.
Protein Name 3'-5' Rna Helicase Ythdc2
Yth Domain-Containing Protein 2
Hythdc2
Database Links
Cellular Localisation Cytoplasm
Perinuclear Region
Alternative Protein Names 3'-5' Rna Helicase Ythdc2 protein
Yth Domain-Containing Protein 2 protein
Hythdc2 protein
YTHDC2 protein

Information sourced from Uniprot.org