Post Translational Modifications | Contains 7 disulfide bonds. N-glycosylated. |
Function | Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal embryonic and postnatal skeleton development, especially of the long bones. Required for normal maturation of chondrocytes during bone development, and normal onset of ossification. |
Protein Name | Xylosyltransferase 1Peptide O-Xylosyltransferase 1Xylosyltransferase IXt-IXylt-I |
Database Links | Reactome: R-HSA-1971475 |
Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecretedDetected Predominantly In The Golgi Apparatus |
Alternative Protein Names | Xylosyltransferase 1 proteinPeptide O-Xylosyltransferase 1 proteinXylosyltransferase I proteinXt-I proteinXylt-I proteinXYLT1 proteinXT1 protein |
Information sourced from Uniprot.org