| Function | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection. Binding to DNA may be mediated by XRCC6. The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription. In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | X-Ray Repair Cross-Complementing Protein 65'-Deoxyribose-5-Phosphate Lyase Ku705'-Drp Lyase Ku7070 Kda Subunit Of Ku AntigenAtp-Dependent Dna Helicase 2 Subunit 1Atp-Dependent Dna Helicase Ii 70 Kda SubunitCtc Box-Binding Factor 75 Kda SubunitCtc75CtcbfDna Repair Protein Xrcc6Lupus Ku Autoantigen Protein P70Ku70Thyroid-Lupus AutoantigenTlaaX-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 6 |
| Database Links | Reactome: R-HSA-164843Reactome: R-HSA-1834949Reactome: R-HSA-3270619Reactome: R-HSA-5693571Reactome: R-HSA-6798695 |
| Cellular Localisation | NucleusChromosome |
| Alternative Protein Names | X-Ray Repair Cross-Complementing Protein 6 protein5'-Deoxyribose-5-Phosphate Lyase Ku70 protein5'-Drp Lyase Ku70 protein70 Kda Subunit Of Ku Antigen proteinAtp-Dependent Dna Helicase 2 Subunit 1 proteinAtp-Dependent Dna Helicase Ii 70 Kda Subunit proteinCtc Box-Binding Factor 75 Kda Subunit proteinCtc75 proteinCtcbf proteinDna Repair Protein Xrcc6 proteinLupus Ku Autoantigen Protein P70 proteinKu70 proteinThyroid-Lupus Autoantigen proteinTlaa proteinX-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 6 proteinXRCC6 proteinG22P1 protein |
Information sourced from Uniprot.org
