Human XRCC3 protein (Recombinant) (His-Tag) (STJP017983)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human XRCC3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | XRCC3 |
| Gene ID | 7517 |
| Uniprot ID | XRCC3_HUMAN |
| Accession Number | NP_005423 |
| Immunogen | Human |
| Immunogen Region | 1-346aa |
| Immunogen Sequence |
Additional Info
| Function | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment.the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process.the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. |
| Protein Name | Dna Repair Protein Xrcc3X-Ray Repair Cross-Complementing Protein 3 |
| Database Links | Reactome: R-HSA-5685942Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionMitochondrionAccumulates In Discrete Nuclear Foci Prior To Dna DamageAnd These Foci Persist Throughout The Time Course Of Dna Repair |
| Alternative Protein Names | Dna Repair Protein Xrcc3 proteinX-Ray Repair Cross-Complementing Protein 3 proteinXRCC3 protein |
Information sourced from Uniprot.org