Human XRCC1 protein (Recombinant) (N-His) (STJP004235)

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STJP004235
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human XRCC1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: XRCC1
Gene ID: 7515
Uniprot ID: XRCC1_HUMAN
Immunogen Region: Thr284-Ala633
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF. Sumoylated.
Function Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity.
Protein Name Dna Repair Protein Xrcc1
X-Ray Repair Cross-Complementing Protein 1
Database Links Reactome: R-HSA-110381
Reactome: R-HSA-5649702
Reactome: R-HSA-5685939
Reactome: R-HSA-5696397
Reactome: R-HSA-6782210
Cellular Localisation Nucleus
Chromosome
Moves From The Nucleoli To The Global Nuclear Chromatin Upon Dna Damage
Recruited To Dna Damage Sites Fowwing Interaction With Poly-Adp-Ribose Chains
Alternative Protein Names Dna Repair Protein Xrcc1 protein
X-Ray Repair Cross-Complementing Protein 1 protein
XRCC1 protein

Information sourced from Uniprot.org

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