Human XPNPEP3 protein (Recombinant) (N-His) (STJP006323)

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STJP006323
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human XPNPEP3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: XPNPEP3
Gene ID: 63929
Uniprot ID: XPP3_HUMAN
Immunogen Region: Glu253-Gln482
Immunogen: Homo sapiens (Human)
Function Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Isoform 1: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B.the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.
Protein Name Xaa-Pro Aminopeptidase 3
X-Pro Aminopeptidase 3
Aminopeptidase P3
App3
Cellular Localisation Isoform 1: Mitochondrion
Cytoplasm
Mainly Mitochondrial
Translocates To The Cytoplasm Following Tnfrsf1b Activation
Isoform 2: Cytoplasm
Alternative Protein Names Xaa-Pro Aminopeptidase 3 protein
X-Pro Aminopeptidase 3 protein
Aminopeptidase P3 protein
App3 protein
XPNPEP3 protein

Information sourced from Uniprot.org

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