| Post Translational Modifications | Auto-ubiquitinated and ubiquitinated by RNF11. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1.the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Activates the Hippo signaling pathway in response to cell contact inhibition and recruitment to the Crumbs complex at the cell membrane. Monoubiquitinates AMOTL2 which facilitates its interaction with and activation of LATS2. LATS2 then phosphorylates YAP1, excluding it from the nucleus and therefore ultimately represses YAP1-driven transcription of target genes. |
| Protein Name | Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp1Atrophin-1-Interacting Protein 5Aip5Hect-Type E3 Ubiquitin Transferase Wwp1Tgif-Interacting Ubiquitin Ligase 1Tiul1Ww Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-1253288Reactome: R-HSA-2672351Reactome: R-HSA-8939902Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinNucleusCell JunctionTranslocates To The Plasma Membrane In Response To Increased Cell-Cell Contact Inhibition And Subsequent Interaction With The Crumbs Complex |
| Alternative Protein Names | Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp1 proteinAtrophin-1-Interacting Protein 5 proteinAip5 proteinHect-Type E3 Ubiquitin Transferase Wwp1 proteinTgif-Interacting Ubiquitin Ligase 1 proteinTiul1 proteinWw Domain-Containing Protein 1 proteinWWP1 protein |
Information sourced from Uniprot.org
