Tissue Specificity | Expressed in brain in the thalamus, in fetal and adult lung and in placenta. |
Post Translational Modifications | Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. |
Function | Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Functions as a upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons. |
Protein Name | Protein Wnt-2Int-1-Like Protein 1Int-1-Related ProteinIrp |
Database Links | Reactome: R-HSA-3238698Reactome: R-HSA-373080 |
Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
Alternative ELISA Names | Protein Wnt-2 ELISA kitInt-1-Like Protein 1 ELISA kitInt-1-Related Protein ELISA kitIrp ELISA kitWNT2 ELISA kitINT1L1 ELISA kitIRP ELISA kit |
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Information sourced from Uniprot.org