| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.054ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This VTCN1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | VTCN1 |
| Gene ID: | 79679 |
| Uniprot ID: | VTCN1_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. |
| Post Translational Modifications | N-glycosylated. |
| Function | Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. |
| Protein Name | V-Set Domain-Containing T-Cell Activation Inhibitor 1 B7 Homolog 4 B7-H4 B7h.5 Immune Costimulatory Protein B7-H4 Protein B7s1 T-Cell Costimulatory Molecule B7x |
| Database Links | |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Expressed At The Cell Surface A Soluble Form Has Also Been Detected |
| Alternative ELISA Names | V-Set Domain-Containing T-Cell Activation Inhibitor 1 ELISA kit B7 Homolog 4 ELISA kit B7-H4 ELISA kit B7h.5 ELISA kit Immune Costimulatory Protein B7-H4 ELISA kit Protein B7s1 ELISA kit T-Cell Costimulatory Molecule B7x ELISA kit VTCN1 ELISA kit B7H4 ELISA kit UNQ659 ELISA kit PRO1291 ELISA kit |
| output |
Information sourced from Uniprot.org
