| Post Translational Modifications | Phosphorylated on tyrosine residues. (Microbial infection) Dephosphorylated by M.tuberculosis PtpA, which induces the reduction of host phagolysosome fusion in M.tuberculosis-infected macrophages. |
| Function | May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 33bHvps33b |
| Database Links | Reactome: R-HSA-9636383Reactome: R-HSA-9754560 |
| Cellular Localisation | Late Endosome MembranePeripheral Membrane ProteinCytoplasmic SideLysosome MembraneEarly EndosomeCytoplasmic VesicleClathrin-Coated VesicleRecycling EndosomeColocalizes In Clusters With Vipas39 At Cytoplasmic OrganellesColocalizes With Rab11a And Vipas39 On Recycling EndosomesColocalizes With Ap-3ClathrinRab5 And Rab7bColocalizes With MTuberculosis Ptpa In The Cytosol Of Tuberculosis-Infected Macrophages And Associates With Phagosomes |
| Alternative Protein Names | Vacuolar Protein Sorting-Associated Protein 33b proteinHvps33b proteinVPS33B protein |
Information sourced from Uniprot.org
