Human visfatin/NAMPT protein (Recombinant) (His-Tag) (STJP019806)

SKU:
STJP019806
£134.50 - £738.50
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human visfatin/NAMPT-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing, 10% Glycerol, 0.1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol: NAMPT
Gene ID: 10135
Uniprot ID: NAMPT_HUMAN
Immunogen Region: 1-491aa
Accession Number: NP_005737
Immunogen: Human
Immunogen Sequence: MNPAAEAEFN ILLATDSYKV THYKQYPPNT SKVYSYFECR EKKTENSKLR KVKYEETVFY GLQYILNKYL KGKVVTKEKI QEAKDVYKEH FQDDVFNEKG WNYILEKYDG HLPIEIKAVP EGFVIPRGNV LFTVENTDPE CYWLTNWIET ILVQSWYPIT VATNSREQKK ILAKYLLETS GNLDGLEYKL HDFGYRGVSS QETAGI
Tissue Specificity Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Function Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
Protein Name Nicotinamide Phosphoribosyltransferase
Namprtase
Nampt
Pre-B-Cell Colony-Enhancing Factor 1
Pre-B Cell-Enhancing Factor
Visfatin
Database Links Reactome: R-HSA-1368108
Reactome: R-HSA-197264
Reactome: R-HSA-9768919
Cellular Localisation Nucleus
Cytoplasm
Secreted
Under Non-Inflammatory Conditions
Visfatin Predominantly Exhibits A Granular Pattern Within The Nucleus
Secreted By Endothelial Cells Upon Il-1beta Stimulation
Abundantly Secreted In Milk
Reaching 100-Fold Higher Concentrations Compared To Maternal Serum
Alternative Protein Names Nicotinamide Phosphoribosyltransferase protein
Namprtase protein
Nampt protein
Pre-B-Cell Colony-Enhancing Factor 1 protein
Pre-B Cell-Enhancing Factor protein
Visfatin protein
NAMPT protein
PBEF protein
PBEF1 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP019805 Mouse visfatin/NAMPT protein (Recombinant) (His-Tag) (STJP019805) E.coli SDS-PAGE
STJP002916 Human PBEF/Visfatin/NAMPT protein (Recombinant) (N-Term 6×His tag) (STJP002916) E.coli
STJP004751 Human NAMPT protein (Recombinant) (N-His) (STJP004751) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP009317 Mouse NAMPT protein (Recombinant) (N-His) (STJP009317) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP018040 Human MVK protein (Recombinant) (His-Tag) (STJP018040) E.coli SDS-PAGE

Related Products

!