Human VEGFD protein (Recombinant-Active) (C-His) (STJP012358)

SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
STJP012358-100
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General Information

Short DescriptionRecombinant-Active-Human VEGFD-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
ApplicationsELISA/WB
HostMammalian Cells
NoteSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

ConjugationUnconjugated
Dilution RangeReconstitute in sterile water for a stock solution.
FormulationLyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage InstructionUse a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin< 1 EU/µg as determined by LAL test.

Target Information

Gene SymbolVEGFD
Gene ID2277
Uniprot IDVEGFD_HUMAN
ImmunogenHomo sapiens (Human)
Immunogen RegionPhe93-Ser201

Additional Info

Post Translational Modifications Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
Function Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Protein Name Vascular Endothelial Growth Factor D
Vegf-D
C-Fos-Induced Growth Factor
Figf
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-194313
Reactome: R-HSA-195399
Cellular Localisation Secreted
Alternative Protein Names Vascular Endothelial Growth Factor D protein
Vegf-D protein
C-Fos-Induced Growth Factor protein
Figf protein
VEGFD protein
FIGF protein

Information sourced from Uniprot.org

Citations

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