| Post Translational Modifications | Phosphorylation at Ser-193 by NEK1 promotes the closed conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. Phosphorylation by the AKT-GSK3B axis stabilizes the protein probably by preventing ubiquitin-mediated proteasomal degradation. Ubiquitinated. Undergoes monoubiquitination and polyubiquitination by PRKN.monoubiquitination at Lys-274 inhibits apoptosis, whereas polyubiquitination leads to its degradation and promotes mitophagy. Deubiquitinated by USP30. |
| Function | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules.in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis.polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells. Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix. Mediates cytochrome c efflux. Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane.the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. |
| Protein Name | Non-Selective Voltage-Gated Ion Channel Vdac1Outer Mitochondrial Membrane Protein Porin 1Plasmalemmal PorinPorin 31hlPorin 31hmVoltage-Dependent Anion-Selective Channel Protein 1Vdac-1Hvdac1 |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-5205685Reactome: R-HSA-5689880Reactome: R-HSA-70268Reactome: R-HSA-8949215 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinCell MembraneMembrane RaftFound In A Complex With Hspa9 And Vdac1 At The Endoplasmic Reticulum-Mitochondria Contact Sites |
| Alternative Protein Names | Non-Selective Voltage-Gated Ion Channel Vdac1 proteinOuter Mitochondrial Membrane Protein Porin 1 proteinPlasmalemmal Porin proteinPorin 31hl proteinPorin 31hm proteinVoltage-Dependent Anion-Selective Channel Protein 1 proteinVdac-1 proteinHvdac1 proteinVDAC1 proteinVDAC protein |
Information sourced from Uniprot.org
