• Human VCAM-1/CD106 protein (Recombinant) (C-His) (STJP001072)
  • Human VCAM-1/CD106 protein (Recombinant) (C-His) (STJP001072)
  • Human VCAM-1/CD106 protein (Recombinant) (C-His) (STJP001072)
  • Human VCAM-1/CD106 protein (Recombinant) (C-His) (STJP001072)

Human VCAM-1/CD106 protein (Recombinant) (C-His) (STJP001072)

SKU:
STJP001072

£59.50 - £156.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human VCAM-1/CD106-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Endotoxin: Please contact us for more information.
Immunoreactivity: Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 10E4 cells/well are added to human VCAM1 coated plates (10 Mu g/mL with 100 Mu L/well) , approximately 80%-90% cells will ad
Gene Symbol: VCAM1
Gene ID: 7412
Uniprot ID: VCAM1_HUMAN
Immunogen: Recombinant Human VCAM-1/CD106 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Phe25-Glu698) of human VCAM1 (Accession #NP_001069.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Cleaved by the metalloproteinase ADAM17 to generate the soluble form. Sialoglycoprotein. Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination.leading to proteasomal degradation.
Function Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.
Protein Name Vascular Cell Adhesion Protein 1
V-Cam 1
Vcam-1
Incam-100
Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-216083
Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Cellular Localisation Vascular Cell Adhesion Protein 1: Cell Membrane
Single-Pass Type I Membrane Protein
Soluble Vascular Cell Adhesion Molecule-1: Secreted
Alternative Protein Names Vascular Cell Adhesion Protein 1 protein
V-Cam 1 protein
Vcam-1 protein
Incam-100 protein
Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1 protein
VCAM1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance