Human USP48 protein (Recombinant) (N-His) (STJP016323)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human USP48-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | USP48 |
| Gene ID | 84196 |
| Uniprot ID | UBP48_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr97-Thr422 |
Additional Info
| Function | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability. In the context of H.pylori infection, stabilizes nuclear RELA through deubiquitination, thereby promoting the transcriptional activity of RELA to prolong TNFAIP3 de novo synthesis. Consequently, TNFAIP3 suppresses caspase activity and apoptotic cell death. Also functions in the modulation of the ciliary and synaptic transport as well as cytoskeleton organization, which are key for photoreceptor function and homeostasis. To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms. Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 48Deubiquitinating Enzyme 48Ubiquitin Thioesterase 48Ubiquitin-Specific Peptidase 48Ubiquitin-Specific Protease 48Ubiquitin-Specific-Processing Protease 48 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmNucleusCell ProjectionCilium |
| Alternative Protein Names | Ubiquitin Carboxyl-Terminal Hydrolase 48 proteinDeubiquitinating Enzyme 48 proteinUbiquitin Thioesterase 48 proteinUbiquitin-Specific Peptidase 48 proteinUbiquitin-Specific Protease 48 proteinUbiquitin-Specific-Processing Protease 48 proteinUSP48 proteinUSP31 protein |
Information sourced from Uniprot.org