| Post Translational Modifications | Acetylated. Sumoylation impairs binding to and hydrolysis of ubiquitin chains. Sumoylated preferentially with SUMO2 or SUMO3. Desumoylated by SENP1. Polyubiquitinated by SMURF1 by promoting the 'Lys-48'-linkage leading to proteasomal degradation. Preferentially monoubiquitinated but can also be polyubiquitinated. Autodeubiquitinated. Ubiquitination activates the enzymatic activity either by preventing sumoylation or by allowing novel interactions. Phosphorylation in the C-terminal by SYK regulates USP25 cellular levels. |
| Function | Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation, immune response. Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2. Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program. Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2. In turn, restricts virus production by regulating cholesterol biosynthetic flux. Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6. Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 25Deubiquitinating Enzyme 25Usp On Chromosome 21Ubiquitin Thioesterase 25Ubiquitin-Specific-Processing Protease 25 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmIsoform Usp25m: CytoplasmNucleusSome Transient Punctuate Nuclear Location In Myotubes During Myocyte Development |
| Alternative Protein Names | Ubiquitin Carboxyl-Terminal Hydrolase 25 proteinDeubiquitinating Enzyme 25 proteinUsp On Chromosome 21 proteinUbiquitin Thioesterase 25 proteinUbiquitin-Specific-Processing Protease 25 proteinUSP25 proteinUSP21 protein |
Information sourced from Uniprot.org
