Human USP21 protein (Recombinant) (N-His) (STJP007851)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human USP21-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | USP21 |
| Gene ID | 27005 |
| Uniprot ID | UBP21_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr220-Leu565 |
Additional Info
| Function | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Deubiquitinates BAZ2A/TIP5 leading to its stabilization. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 21Deubiquitinating Enzyme 21Ubiquitin Thioesterase 21Ubiquitin-Specific-Processing Protease 21 |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Ubiquitin Carboxyl-Terminal Hydrolase 21 proteinDeubiquitinating Enzyme 21 proteinUbiquitin Thioesterase 21 proteinUbiquitin-Specific-Processing Protease 21 proteinUSP21 proteinUSP23 proteinPP1490 protein |
Information sourced from Uniprot.org