Name: Human USP21 protein (Recombinant) (N-His) (STJP007851)
SKU: STJP007851
Availability: InStock

Human USP21 protein (Recombinant) (N-His) (STJP007851)

SKU:

STJP007851

£328.50 - £1,437.50

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Host:	E. coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human USP21-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Function	Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Deubiquitinates BAZ2A/TIP5 leading to its stabilization. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination.
Protein Name	Ubiquitin Carboxyl-Terminal Hydrolase 21 Deubiquitinating Enzyme 21 Ubiquitin Thioesterase 21 Ubiquitin-Specific-Processing Protease 21
Database Links	Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-5357956 Reactome: R-HSA-5689880
Cellular Localisation	Cytoplasm Nucleus
Alternative Protein Names	Ubiquitin Carboxyl-Terminal Hydrolase 21 protein Deubiquitinating Enzyme 21 protein Ubiquitin Thioesterase 21 protein Ubiquitin-Specific-Processing Protease 21 protein USP21 protein USP23 protein PP1490 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP005172	Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172)	E. coli
STJP004723	Human WAS protein (Recombinant) (N-His) (STJP004723)	E. coli
STJP011684	Human OTUD4 protein (Recombinant) (N-His) (STJP011684)	E. coli
STJP011639	Human ERFE protein (Recombinant) (N-His) (STJP011639)	E. coli
STJP011680	Human TMED3 protein (Recombinant) (N-His) (STJP011680)	E. coli

Human USP21 protein (Recombinant) (N-His) (STJP007851)

General Information