| Function | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis. Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination. Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization. Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1. Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability. Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 20Deubiquitinating Enzyme 20Ubiquitin Thioesterase 20Ubiquitin-Specific-Processing Protease 20Vhl-Interacting Deubiquitinating Enzyme 2Hvdu2 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Protein Names | Ubiquitin Carboxyl-Terminal Hydrolase 20 proteinDeubiquitinating Enzyme 20 proteinUbiquitin Thioesterase 20 proteinUbiquitin-Specific-Processing Protease 20 proteinVhl-Interacting Deubiquitinating Enzyme 2 proteinHvdu2 proteinUSP20 proteinKIAA1003 proteinLSFR3A proteinVDU2 protein |
Information sourced from Uniprot.org
