Human USP14 (Ubiquitin Specific Peptidase 14) Sandwich ELISA Kit Ready-To-Use Kit (STJE0019342)
SPECIFICATIONS
General Information
| Short Description | This USP14 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.108ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | USP14 |
| Gene ID | 9097 |
| Uniprot ID | UBP14_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation. Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 14Deubiquitinating Enzyme 14Ubiquitin Thioesterase 14Ubiquitin-Specific-Processing Protease 14 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-9758274 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative ELISA Names | Ubiquitin Carboxyl-Terminal Hydrolase 14 ELISA kitDeubiquitinating Enzyme 14 ELISA kitUbiquitin Thioesterase 14 ELISA kitUbiquitin-Specific-Processing Protease 14 ELISA kitUSP14 ELISA kitTGT ELISA kit |
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Information sourced from Uniprot.org